Titin N-Fragment ELISA

Tecan IBL Titin Overview

General Characteristics:

• Size and Structure: Titin is the largest known protein in the human body, consisting of 34,350 amino acids with a molecular weight of approximately 3,816 kDa. It is also known as connectin.
• Function: Titin functions as a molecular spring within muscle cells, aiding in the assembly of myofibrils and contributing to the elastic properties of muscle. It is crucial for maintaining sarcomere structure and facilitating the recovery of muscle length after contraction.

Biological Role:

• Sarcomere Function: Titin is integral to the sarcomere, the fundamental unit of muscle contraction. It helps restore the sarcomere to its original length following muscle contraction by acting as an elastic protein.
• Protein Cleavage: In response to muscle damage, titin can be cleaved by metabolic enzymes such as calpain and matrix metalloproteases. This cleavage can be indicative of muscle injury or disease.

Clinical Relevance:

• Research Applications: Titin is studied in various fields including sports medicine, cardiac diseases, Non-Alcoholic Fatty Liver Disease (NAFLD), sarcopenia, and frailty. Its extensive size and role in muscle function make it a key focus in these areas.
• Biomarker Potential: The N-terminal fragment of titin, known as Titin N-fragment, has emerged as a potential non-invasive biomarker for assessing muscle status. This fragment is measurable in urine, offering a practical approach for monitoring muscle health and damage.

Diagnostic Tools:

• ELISA Kit: The ELISA kit designed for measuring the Titin N-terminal fragment in urine provides a valuable tool for non-invasive muscle monitoring. This kit can be utilized in research and clinical settings to evaluate muscle status and track changes over time.

Control Sets:

• Additional Controls: A separate control set for this ELISA kit is available upon request, ensuring accurate and reliable measurements of the Titin N-terminal fragment.

Summary

• Titin Function and Size: Titin is a critical protein in muscle cells, functioning as an elastic protein and a structural component of the sarcomere. Its enormous size and elastic properties are essential for muscle function and recovery.
• Clinical Applications: Research into titin’s role extends to several medical fields, including muscle diseases and metabolic disorders. The Titin N-fragment is a promising biomarker for muscle status, with an ELISA kit available for measuring this fragment in urine.

This ELISA Kit from Tecan IBL International is for research use only.

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