Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Recombinant Mouse Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) for Migration Assays
Product Overview: Recombinant Mouse Stromal Cell-Derived Factor 1α (SDF-1α), also known as CXCL12, is an 8 kDa chemokine protein with significant roles in various physiological processes. It exhibits approximately 92% homology with its counterparts in human, mouse, and rat species.
Functions of SDF-1α:
- Leukocyte Trafficking: Regulates the migration and localization of immune cells, playing a key role in immune responses.
- Hematopoiesis: Influences the formation and development of blood cells within the bone marrow.
- Organogenesis: Contributes to the formation and development of organs during embryogenesis.
- Cell Differentiation and Tissue Regeneration: Supports cell differentiation processes and aids in tissue repair and regeneration.
Mechanism of Action:
- Receptor Binding: SDF-1α exerts its effects by binding to the CXCR4 receptor on target cells.
- Interaction with HMGB1: Forms a heterocomplex with HMGB1 (High Mobility Group Box 1), enhancing cell recruitment via CXCR4. This interaction underscores its role in the coordination of cell migration and immune responses.
Product Details:
- Form: Recombinant protein
- Intended Use: For research purposes only
- Regulatory Status: Not approved for use in humans
Applications:
- Migration Assays: Useful for studying cell migration and chemotaxis in various experimental models.
- Immune Cell Research: Facilitates investigation into immune cell trafficking and recruitment mechanisms.
- Hematopoietic Studies: Aids in the exploration of blood cell formation and differentiation processes.
- Tissue Regeneration: Supports research into cell differentiation and tissue repair.
This recombinant SDF-1α is a valuable tool for research into the fundamental processes of cell migration, immune response, and tissue regeneration.
This Immunoassay from Tecan IBL International is for research use only.
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