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90K/Mac-2 BP: Overview and Potential Roles
Introduction: 90K/Mac-2 BP is a secreted glycoprotein with a molecular weight of approximately 90 kDa. It was initially discovered in the supernatant of human breast cancer cells and is also known as Mac-2 BP, highlighting its association with the Mac-2 lectin.
Key Characteristics:
- Molecular Weight: 90 kDa
- Expression: Found in human serum and widely expressed across various tissues.
- Identification: Identical to Mac-2 BP, a ligand for the S-lectin Mac-2.
Biological Functions and Potential Roles:
- Mac-2 Binding:
- Mac-2 Lectin Interaction: 90K/Mac-2 BP functions as a ligand for the Mac-2 lectin (S-lectin), which is specific for lactose and galactose. Mac-2 is expressed by macrophages, monocytes, and various other cell types.
- Immune Defense Mechanisms:
- Immune Response: Although the precise biological functions of 90K/Mac-2 BP are not fully elucidated, it is hypothesized to play a role in immune defense. Its interaction with Mac-2 suggests it may be involved in modulating immune responses or participating in immune surveillance.
- Cancer Research:
- Cancer Association: The identification of 90K/Mac-2 BP in breast cancer cell supernatants raises questions about its role in cancer. Further research may uncover its potential involvement in cancer progression, metastasis, or immune evasion mechanisms.
- Diagnostic and Therapeutic Potential:
- Biomarker Potential: Given its expression pattern and association with cancer cells, 90K/Mac-2 BP might be explored as a biomarker for certain diseases, including cancer. Its role in immune responses also suggests potential therapeutic applications or targets.
Research Implications:
- Function Elucidation: Ongoing research is needed to define the exact biological functions and mechanisms through which 90K/Mac-2 BP contributes to immune responses and disease processes.
- Clinical Applications: Understanding its role in cancer and immune defense could lead to new diagnostic or therapeutic strategies.
Conclusion: 90K/Mac-2 BP is a versatile glycoprotein with potential roles in immune defense and cancer. While its precise biological functions are still under investigation, its interaction with Mac-2 lectin and its presence in cancer cell supernatants suggest it could be significant in both immunology and oncology. Further research will be essential to fully understand its functions and potential applications in clinical settings.
This ELISA Kit from Tecan IBL International is for research use only.
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