NF-Light® Serum ELISA

Serum NF-light™ ELISA: Overview and Applications

Introduction: The Serum NF-light™ ELISA is a specialized assay designed for the quantitative measurement of human Neurofilament light (NF-L) protein in serum samples. NF-L is a key component of neurofilaments, which are intermediate filaments found in neurons and play a crucial role in maintaining neuronal structure and function.

Key Features:

• Assay Type: ELISA (Enzyme-Linked Immunosorbent Assay)
• Target Protein: Neurofilament light (NF-L)
• Species: Primarily for human serum; applicable to other species including rat, mouse, bovine, and macaque
• Intended Use: Research Use Only (RUO)

Applications:

1. Neurodegenerative Disease Research:
• Multiple Sclerosis: Elevated levels of NF-L in serum can be used as a biomarker for disease activity and progression in multiple sclerosis.
• Alzheimer's Disease: NF-L levels may provide insights into neuronal damage and disease progression.
• Amyotrophic Lateral Sclerosis (ALS): NF-L measurement can aid in monitoring disease progression and assessing therapeutic responses.
2. Traumatic Brain Injury:
• NF-L levels in serum can be used to evaluate the extent of neuronal damage following traumatic brain injury.
3. General Neurological Research:
• The assay can be utilized to study neuronal damage and repair mechanisms in various experimental models and conditions.
4. Cross-Species Studies:
• Although primarily designed for human samples, the NF-light™ ELISA is versatile and can also measure NF-L in serum from other species, including rat, mouse, bovine, and macaque. This allows researchers to study NF-L in preclinical animal models and comparative studies.

Assay Details:

• Quantitative Measurement: Provides precise quantification of NF-L levels in serum.
• Antibodies: The assay uses antibodies that recognize NF-L across different species, making it adaptable for various research needs.

Usage:

• Research Settings: This ELISA is intended for use in research environments and is not approved for clinical diagnostics or therapeutic monitoring.
• Professional Use: Designed for use by researchers and professionals familiar with ELISA techniques and neurobiological studies.

Conclusion: The Serum NF-light™ ELISA is a powerful tool for measuring NF-L levels in serum samples, providing valuable insights into neuronal damage and disease mechanisms in various research contexts. Its versatility across species enhances its utility in preclinical studies and comparative research.

This ELISA Kit from Tecan IBL International is for research use only.

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