N-ERC/Mesothelin ELISA

ERC (Mesothelin) Overview

Identification and Homology:

• Initial Discovery: Identified in cancer-affected renal tissue of Eker rats.
• Human Homolog: Mesothelin, also known as MPF (megakaryocyte potentiating factor).

Expression and Role:

• Human Expression: Mesothelin is expressed in mesothelial cells.
• Cancer Associations: Plays a role in the development of various cancers, including:
• Mesothelioma
• Pancreatic Cancer
• Ovarian Cancer
• Pulmonary Cancers

Protein Structure and Processing:

• Type: Glycosylphosphatidylinositol (GPI)-anchored membrane protein.
• Molecular Weight: Approximately 71 kDa.
• Cleavage:
• Protease: Cleaved by a Furin-like protease.
• Fragments: Results in two fragments:
• 31 kDa N-terminal Fragment: Known as N-ERC or mesothelin.
• 40 kDa C-terminal Fragment

ELISA Kit Specifics:

• Purpose: Measures the 31 kDa N-terminal fragment (N-ERC or mesothelin) in plasma samples.
• Intended Use: For research purposes only; not for clinical diagnostic use.

Significance in Research:

• Cancer Biomarker: The detection of mesothelin levels can be useful in research on cancer progression and diagnosis.
• Target for Drug Development: Due to its role in cancer, mesothelin is a potential target for therapeutic interventions.

Usage Note:

• Research Only: This ELISA kit is intended for use in research settings to study the presence and levels of the mesothelin protein in plasma samples, aiding in understanding its role in cancer and other diseases.

This ELISA Kit from Tecan IBL International is for research use only.

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