Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Tecan IBL PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1)
General Characteristics:
- Molecular Weight: Approximately 130 kDa, with variability due to glycosylation.
- Structure: Transmembrane glycoprotein.
Expression and Localization:
- Vascular Cells: Ubiquitously expressed on all vascular cells, making it a valuable marker for blood vessels in angiogenesis studies.
- Other Cells: Found on platelets, monocytes, neutrophils, CD8+ T cells, bone marrow stem cells, and transformed cell lines (myeloid and megakaryocytic). Also observed on solid tumor lines from various species (humans, mice, rats).
Functions and Roles:
- Leukocyte-Endothelial Interactions: Involved in inflammation and the interaction between leukocytes and endothelial cells.
- Angiogenesis Marker: PECAM-1 is an early and sensitive marker for tumor-induced angiogenesis, reflecting its role in new blood vessel formation.
- Development and Metastasis: Suggests involvement in angiogenesis during vertebrate embryonic development and in metastasis formation.
Soluble Form:
- Characteristics: A soluble form of PECAM-1 is 5-10 kDa smaller than the membrane-bound form and includes the cytoplasmic tail.
- Detection: Soluble PECAM-1 has been detected in normal human plasma.
Summary: PECAM-1 is a key adhesion molecule present on a wide range of cells, including vascular cells, platelets, and immune cells. Its role in angiogenesis and inflammation, along with its presence in both membrane-bound and soluble forms, makes it a significant marker for blood vessels and tumor-related processes. The detection of PECAM-1, especially in its soluble form, provides insights into vascular biology and tumor progression.
This ELISA Kit from Tecan IBL International is for research use only.
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