Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
N-ERC/Mesothelin ELISA Kit
Purpose: The N-ERC/Mesothelin ELISA Kit is designed to accurately quantify the N-terminal fragment of ERC (N-ERC/Mesothelin) in various biological samples, including tumor cell lines, serum, and plasma. This assay facilitates detailed analysis of ERC expression and its association with cancer.
Background: ERC is a gene with elevated expression in cancerous renal cells compared to normal renal tissue and has been studied in Eker rats, a model for renal cancer. The human equivalent of the ERC-encoded protein is known as MPF (megakaryocyte potentiating factor) or mesothelin. Mesothelin is a GPI-anchored membrane protein with a molecular weight of approximately 71 kDa. It is predominantly expressed in mesothelial cells and has been implicated in mesothelioma, as well as various other cancers such as pancreatic, ovarian, and pulmonary cancers.
The mesothelin protein is cleaved by a furin-like protease into two fragments: approximately 31 kDa (N-ERC/Mesothelin) and 40 kDa (C-ERC/Mesothelin). The N-ERC/Mesothelin fragment, which is the focus of this assay, plays a significant role as a tumor marker and is valuable for studying its expression and association with cancerous conditions.
Significance: Quantifying N-ERC/Mesothelin is crucial for understanding its role in cancer and its potential as a biomarker for various malignancies. This ELISA kit provides specific and accurate measurement of N-ERC/Mesothelin, supporting research into its expression patterns and relevance in cancer diagnosis and monitoring.
Assay Details:
- Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
- Target: N-ERC/Mesothelin (31 kDa fragment)
- Specificity: Designed to specifically detect the N-ERC/Mesothelin fragment with high accuracy
- Sensitivity: Optimized for reliable detection of low levels of N-ERC/Mesothelin
- Format: Includes ready-to-use reagents and a comprehensive protocol
- Sample Types: Compatible with tumor cell lines, serum, and plasma samples
Utility: The N-ERC/Mesothelin ELISA Kit is a valuable tool for:
- Investigating ERC/Mesothelin expression in cancer research
- Evaluating the role of N-ERC/Mesothelin in various cancers, including mesothelioma, pancreatic, ovarian, and pulmonary cancers
- Conducting biomarker studies for cancer diagnosis and monitoring
By providing precise measurement of N-ERC/Mesothelin, this ELISA kit supports advanced research and contributes to the development of targeted cancer therapies and diagnostic tools.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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