Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Leucine-Rich Alpha-2-Glycoprotein (LRG) ELISA Kit for Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus (iNPH)
Purpose: The Leucine-Rich Alpha-2-Glycoprotein (LRG) ELISA Kit is designed to quantify LRG levels in cerebrospinal fluid (CSF), blood, or urine samples. This assay aids in the differential diagnosis of Idiopathic Normal Pressure Hydrocephalus (iNPH) from other neurodegenerative disorders, including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), and Parkinson’s disease-related conditions.
Background: Idiopathic Normal Pressure Hydrocephalus (iNPH) often presents with gait disturbances, cognitive decline, and dementia, symptoms that can overlap with other neurodegenerative diseases. Accurate differentiation between iNPH and these disorders is essential for effective treatment, as iNPH can be managed with a ventriculo-peritoneal shunt (VP shunt), whereas other conditions may require different interventions.
Research conducted by Arai, Miyajima, and colleagues has demonstrated that elevated levels of leucine-rich alpha-2-glycoprotein (LRG) in the CSF are associated with iNPH. Their studies suggest that measuring LRG levels could provide a valuable diagnostic tool for distinguishing iNPH from similar neurodegenerative diseases.
Significance: Accurate and early diagnosis of iNPH is crucial for appropriate treatment and improved patient outcomes. The LRG ELISA Kit offers a reliable method for detecting elevated LRG levels, which can help clinicians differentiate iNPH from other conditions with overlapping symptoms, leading to timely and effective intervention.
Assay Details:
- Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
- Target: Leucine-Rich Alpha-2-Glycoprotein (LRG)
- Specificity: Designed to measure LRG in CSF, blood, and urine samples
- Sensitivity: Optimized for accurate detection of LRG at low concentrations
- Format: Includes ready-to-use reagents and a detailed protocol for ease of use
- Sample Types: Compatible with cerebrospinal fluid, blood, and urine
Utility: The LRG ELISA Kit is valuable for:
- Differentiating iNPH from Alzheimer’s disease, FTLD, and Parkinson’s disease-related conditions
- Monitoring LRG levels in various biological fluids to support diagnostic decisions
- Facilitating early diagnosis and intervention for iNPH, potentially improving patient outcomes
By providing precise measurement of LRG, this ELISA kit supports the accurate diagnosis of iNPH, contributing to better-targeted treatments and enhanced patient care
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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