Leptin high sensitive ELISA

Leptin ELISA Kit

Purpose: The Leptin ELISA Kit is designed to accurately measure leptin levels in biological samples. Leptin, a key regulator of energy balance and metabolism, is crucial for understanding obesity, type II diabetes, and related metabolic disorders.

Background: The recessive obesity mutation, known as ob, was first identified in 1950 and is associated with severe obesity and type II diabetes, closely resembling morbid obesity in humans. In 1994, a groundbreaking study by Jeffrey Friedman and his team at Rockefeller University identified the gene responsible for this condition, which encodes the protein leptin.

Leptin is a 16 kDa secreted protein produced by the ob gene and synthesized primarily by adipose tissue. It is released into the bloodstream, where its levels typically increase with fat accumulation. As a lipostat, leptin reflects the amount of fat stored in adipocytes. It functions as a hormone that signals the brain to reduce food intake and increase physical activity. Additionally, leptin is involved in regulating the onset of puberty and has been recently shown to potentially inhibit bone formation through its effects on the central nervous system.

Significance: Leptin measurement is essential for:

• Understanding Obesity: Elevated leptin levels can be indicative of obesity and its related complications, such as type II diabetes.
• Research on Metabolic Disorders: Leptin's role in energy balance, appetite regulation, and its effects on puberty and bone formation are crucial for studying various metabolic and developmental disorders.
• Monitoring Therapeutic Interventions: Tracking leptin levels can help evaluate the effectiveness of treatments aimed at managing obesity and related conditions.

Assay Details:

• Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
• Target: Leptin
• Specificity: Designed to accurately measure leptin levels in various biological samples
• Sensitivity: Optimized for detecting leptin at low concentrations
• Format: Includes ready-to-use reagents and a comprehensive protocol
• Sample Types: Suitable for serum, plasma, and other relevant biological fluids

Utility: The Leptin ELISA Kit is valuable for:

• Research: Investigating the role of leptin in obesity, diabetes, and related metabolic disorders
• Clinical Diagnostics: Assessing leptin levels for diagnostic and monitoring purposes in obesity and other conditions
• Therapeutic Monitoring: Evaluating the impact of interventions on leptin levels and related metabolic outcomes

By providing precise measurement of leptin, this ELISA kit supports research and clinical efforts to better understand and manage obesity and its associated conditions.

This ELISA Kit from Tecan IBL International is for research use only.

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