Interleukin-6 Receptor (IL-6R) ELISA

Interleukin-6 (IL-6) and Soluble IL-6 Receptor (sIL-6R)

Overview:

• IL-6 Function: IL-6 is a multifunctional cytokine crucial for:
• Immune Response Regulation
• Hematopoiesis
• Acute Phase Response
• Receptor Structure:
• IL-6 Receptor: Comprised of two subunits:
• gp80 (80 kDa): The ligand-binding subunit.
• gp130 (130 kDa): The signal-transducing protein.
• Both subunits are part of the hematopoietic receptor superfamily.

Soluble IL-6 Receptor (sIL-6R):

• Formation:
• Soluble Form: The soluble form of the IL-6 receptor (sIL-6R) is derived from the extracellular portion of gp80.
• Shedding: Generated by shedding, a process regulated by protein kinase C.
• Size: The soluble receptor is 55 kDa.
• Function:
• Despite being soluble, sIL-6R remains functional and acts as an agonist in conjunction with IL-6 to promote IL-6 activity.

Clinical Significance:

• Human Immunodeficiency Virus (HIV):
• Elevated sIL-6R levels are observed in HIV-infected patients.
• Multiple Myeloma (MM) and Monoclonal Gammopathy of Undetermined Significance (MGUS):
• Increased serum levels of sIL-6R are found in patients with MM and MGUS.
• These elevated levels are independent of other prognostic factors like serum IL-6 levels and myeloma cell mass.
• Hodgkin's Disease (HD):
• Elevated IL-6 receptor expression is noted in the mixed cellularity subtype of Hodgkin's disease.

Summary: IL-6 plays a vital role in various physiological processes and is implicated in several pathological conditions. The soluble form of the IL-6 receptor (sIL-6R) continues to contribute to IL-6 signaling, influencing disease progression and providing potential biomarkers for monitoring certain conditions, including HIV, multiple myeloma, and Hodgkin's disease.

This ELISA Kit from Tecan IBL International is for research use only.

Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
Explore the full range >