Syndecan-4 ELISA

Syndecan Family Overview

General Characteristics:

• Type: Transmembrane heparan sulfate proteoglycans (HSPGs)
• Function: These proteins are involved in various cellular processes, including cell adhesion, signaling, and proliferation.

Family Members:

1. Syndecan-1 (Syndecan):
• Distribution: Primarily expressed in epithelial cells, including vascular endothelial cells.
• Functions: Involved in cell-cell and cell-matrix interactions, influencing cell behavior and tissue organization.
2. Syndecan-2 (Fibroglycan):
• Distribution: Found in fibroblasts and vascular endothelial cells.
• Functions: Plays a role in cell migration and matrix organization.
3. Syndecan-3 (N-Syndecan):
• Distribution: Expressed in neurons and other tissues.
• Functions: Involved in neural cell adhesion and axon guidance.
4. Syndecan-4 (Ryudocan or Amphyglycan):
• Distribution: Present in various cell types, including endothelial cells and fibroblasts.
• Functions: Contributes to cell adhesion, migration, and signaling through interactions with focal adhesion molecules.

Molecular Structure:

• Type I Integral Membrane Proteins: Each syndecan family member features a single transmembrane domain and a cytoplasmic tail.
• Cytoplasmic Domain: Contains four well-conserved tyrosine residues, which are crucial for their biological functions.
• Heparan Sulfate Chains: Attached to the extracellular domain, these glycosaminoglycans interact with a variety of ligands, influencing cell signaling and adhesion.

Biological Functions:

• Anticoagulation: Syndecan-4, in particular, has been linked to anticoagulant properties.
• Cell Adhesion: These proteoglycans mediate interactions between cells and the extracellular matrix, affecting tissue structure and function.
• Cell Proliferation: Syndecans can influence cell growth and division, contributing to tissue development and repair.

Clinical Relevance:

• Cancer: Syndecan expression levels can be altered in cancer, influencing tumor progression and metastasis.
• Wound Healing: Syndecans play roles in tissue repair and wound healing processes.
• Inflammation: Dysregulation of syndecans can contribute to inflammatory diseases and pathological conditions.

Understanding the roles of syndecans in various biological contexts provides insights into their potential as therapeutic targets for diseases involving cell adhesion, migration, and proliferation.

This ELISA Kit from Tecan IBL International is for research use only.

Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
Explore the full range >