Code: 30123114
Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Price on Application
Tecan IBL Amyloid-β (Amyloid-beta) 42 Oligomerization in Alzheimer's Disease
Context and Importance:
- Early Event in Alzheimer's Disease (AD): The oligomerization of Amyloid-β (Aβ) 42 is an early and critical event in Alzheimer's disease pathology. These oligomers are believed to contribute significantly to neurotoxicity and cognitive decline.
- Toxic Conformer: Research by Irie et al. has identified a specific Aβ conformer with a turn structure at positions 22 and 23 that exhibits high toxicity and is prone to forming neurotoxic oligomers. This conformer has been found to be stable and more likely to aggregate into harmful forms.
Research and Diagnostic Tools:
- Antibody Development: An antibody (clone: 24B3) has been developed to specifically detect this toxic Aβ conformer. This antibody is crucial for distinguishing the toxic forms of Aβ from other less harmful conformers.
- ELISA Kit: The ELISA assay kit utilizing this antibody allows for the selective measurement of the toxic Aβ oligomer in cerebrospinal fluid (CSF). This measurement can be useful for both research into Alzheimer's disease and for diagnostic purposes.
Kit Availability:
- Additional Controls: A separate control set for this ELISA kit is available upon request, ensuring accurate calibration and validation of the assay results.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
Explore the full range >