Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Full-Length HMGB1 for Mass Spectrometry and NMR Studies
Product Overview: HMGB1 (High Mobility Group Box 1) is an essential nuclear protein that plays a pivotal role in various cellular processes. It is involved in the regulation of gene expression, DNA repair, and chromatin structure. HMGB1 is passively released by necrotic cells, retained by apoptotic cells, and actively secreted by inflammatory cells. Given its critical role in cellular functions, HMGB1 knockout mice experience severe developmental issues and die shortly after birth.
Functional Forms of HMGB1:
- Chemoattractant Activity: Full-Length HMGB1 exhibits chemoattractant properties, promoting the migration of various cell types.
- Cytokine Induction: Specific redox forms of HMGB1 are responsible for inducing cytokine production and modulating immune responses.
Product Details:
- Protein: Full-Length HMGB1
- Molecular Weight: 25 kDa
- Labeling: Isotopically labeled with 15N for enhanced resolution in mass spectrometry and NMR studies.
- Source: Produced in E. coli, corresponding to the human HMGB1 sequence.
- Intended Use: Suitable for mass spectrometry and NMR spectroscopy studies.
Applications:
- Structural Analysis: Ideal for detailed structural characterization of HMGB1 using NMR spectroscopy.
- Functional Studies: Enables in-depth functional studies of HMGB1’s interaction with DNA and other cellular components.
- Mass Spectrometry: Facilitates precise analysis of HMGB1’s molecular weight, structure, and modifications.
Product Benefits:
- High Purity: Ensures accurate and reliable results in structural and functional studies.
- Isotopic Labeling: Enhances detection and analysis in mass spectrometry and NMR, providing detailed insights into HMGB1’s structure and interactions.
This Full-Length HMGB1 protein is an invaluable resource for researchers investigating the molecular mechanisms of HMGB1 and its role in various biological processes.
This Immunoassay from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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