Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
HB-EGF (Heparin-binding EGF-like Growth Factor) Overview
Family and Function:
- Family: EGF (Epidermal Growth Factor) family.
- Receptor Interaction: Acts as a ligand for ErbB receptor tyrosine kinases, including EGF receptor (EGFR), ErbB2, and ErbB4.
- Roles: Involved in cell proliferation, differentiation, migration, and inflammatory responses.
Forms of HB-EGF:
- ProHB-EGF (Transmembrane Form):
- Location: Embedded in the cell membrane.
- Function: The precursor form, which is proteolytically processed to release other forms of HB-EGF.
- sHB-EGF (Soluble Form):
- Formation: Produced by proteolytic cleavage of ProHB-EGF at the cell surface.
- Function: This soluble form is involved in autocrine and paracrine signaling, influencing cell growth and inflammation.
- HB-EGF-CTF (C-terminal Fragment):
- Location: Remains attached to the cell membrane after cleavage of ProHB-EGF.
- Function: The C-terminal fragment continues to interact with cell surface receptors and contributes to signaling processes.
Expression and Roles:
- Cell Types: Expressed in a variety of cell types including epidermal cells, cardiac myocytes, vascular endothelial cells, smooth muscle cells, and macrophages.
- Physiological Roles:
- Cell Proliferation and Differentiation: Promotes growth and differentiation of various cell types.
- Inflammatory Responses: Involved in modulating inflammation.
- Cancer Invasion and Metastasis: HB-EGF has been implicated in cancer progression and metastasis due to its role in promoting cell migration and proliferation.
Receptor for Diphtheria Toxin:
- Function: HB-EGF acts as a receptor for diphtheria toxin, which can utilize HB-EGF to enter cells.
Clinical and Research Implications:
- Drug Development: Due to its roles in cancer and cell proliferation, HB-EGF is a target for therapeutic development in oncology and other diseases involving aberrant cell growth.
- Research Applications: The HB-EGF ELISA kit specifically measures the form containing the propeptide, useful for research into HB-EGF’s role in various physiological and pathological processes.
ELISA Kit Details:
- Purpose: Measures the human HB-EGF form containing the propeptide.
- Intended Use: For research purposes only; not for clinical diagnostic procedures.
- Additional Notes: The ELISA kit provides a means to quantify HB-EGF levels and investigate its biological roles and potential as a therapeutic target.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
Explore the full range >