GRO/KC (mouse) ELISA

Mouse KC (Keratinocyte-derived Cytokine) and Mouse MIP (Macrophage Inflammatory Protein) are important cytokines involved in inflammatory responses and leukocyte chemotaxis. Here’s a detailed overview of both:

Mouse KC (Keratinocyte-derived Cytokine)

• Homologous to Human GRO: Mouse KC is analogous to the human GRO (Growth-Regulated Oncogene) protein, which is part of the CXC chemokine family. Both are involved in similar biological processes, including inflammation and cell migration.
• Production and Expression: KC is primarily produced by activated monocytes, fibroblasts, and keratinocytes. It is released in response to inflammatory stimuli, playing a role in the recruitment and activation of immune cells.
• Functions:
• Chemotaxis: KC is a potent chemoattractant for neutrophils, promoting their migration to sites of inflammation.
• Inflammatory Response: It contributes to the local inflammatory response and can influence tissue remodeling and repair.
• Biological Impact: KC's involvement in inflammation makes it relevant for studying conditions such as chronic inflammatory diseases, wound healing, and various autoimmune disorders.

Mouse MIP (Macrophage Inflammatory Protein)

• Discovery and Types: Mouse MIP was first identified as a small protein (approximately 8 kDa) induced in macrophages by lipopolysaccharide (LPS) stimulation. Research has subsequently identified two major types:
• MIP-1: Often referred to as MIP-1α, it is a member of the CC chemokine family and plays a role in attracting leukocytes to sites of inflammation.
• MIP-2: Also known as MIP-2α, this chemokine has similar functions but can differ in its specific activities and target cells compared to MIP-1.
• Functions:
• Leukocyte Chemotaxis: MIP proteins are involved in the directed migration of various types of leukocytes, including monocytes and neutrophils.
• Inflammatory Response: They are key mediators in the recruitment of immune cells during inflammatory processes.
• Biological Impact: MIP-1 and MIP-2 are crucial in understanding the mechanisms underlying inflammation and immune responses. They are involved in conditions such as infections, autoimmune diseases, and cancer.

Summary

Both Mouse KC and Mouse MIP proteins are central to the regulation of immune responses and inflammation. KC, as a counterpart to human GRO, primarily influences neutrophil chemotaxis and inflammation, while MIP-1 and MIP-2 are critical in leukocyte recruitment and activation during inflammatory responses. Their roles in these processes make them significant in both basic research and potential therapeutic applications related to inflammatory and immune-related diseases.

This ELISA Kit from Tecan IBL International is for research use only.

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