GIP Total (Rat) High Sensitivity ELISA

Gastric Inhibitory Peptide (GIP) Overview

Function and Role:

• Incretin Hormone: GIP is a key gastrointestinal hormone that stimulates insulin secretion from pancreatic beta cells following food intake and inhibits glucagon release from pancreatic alpha cells.
• Nutrient Retention: Essential for retaining ingested nutrients within the body by affecting cells such as pancreatic beta cells, adipocytes, and osteoblastic cells.

Discovery and Naming:

• Original Discovery: Initially identified as “gastric inhibitory peptide” in 1970 from intestinal mucosa.
• Renaming: Renamed to “glucose-dependent insulinotropic peptide” to reflect its role in insulin secretion.

Biochemical Characteristics:

• Forms:
• Active Form (GIP 1-42): The biologically active form that has physiological effects.
• Inactive Form (GIP 3-42): Formed from GIP 1-42 by the enzyme Dipeptidyl Peptidase-IV (DPP-IV), leading to rapid inactivation.

Receptor and Expression:

• GIP Receptor Presence: Found in various cell types including:
• Pancreatic Beta Cells: Involved in insulin secretion.
• Adipocytes: Influences fat metabolism.
• Osteoblastic Cells: Affects bone growth and metabolism.

Clinical Relevance:

• Metabolic Syndrome: Modulating GIP signaling is a potential strategy for improving conditions related to metabolic syndrome, including obesity and type 2 diabetes.

ELISA Kit Features:

• Purpose: Specifically measures the active form of Mouse GIP (1-42) in blood samples.
• Components: Includes all necessary reagents for conducting quantitative enzyme-linked immunosorbent assays (ELISA).
• Control Set: Available separately upon request.

This ELISA kit is designed to accurately quantify the active form of GIP (1-42), aiding in research related to metabolic health and GIP's physiological roles.

This ELISA Kit from Tecan IBL International is for research use only.

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