GIP Total (Mouse) High Sensitivity ELISA

Gastric Inhibitory Peptide (GIP) Overview

Function and Role:

• Incretin Hormone: GIP is a gastrointestinal hormone that stimulates insulin secretion from pancreatic beta cells in response to food intake and inhibits glucagon release from pancreatic alpha cells.
• Nutrient Regulation: Plays a key role in regulating nutrient retention and metabolic processes in various cell types, including pancreatic beta cells, adipocytes, and osteoblastic cells.

Biochemical Characteristics:

• Discovery: GIP, initially known as Gastric Inhibitory Peptide, was first identified and sequenced from intestinal mucosa in 1970. It was later renamed glucose-dependent insulinotropic peptide.
• Forms:
• Active Form (GIP 1-42): The biologically active form of the peptide.
• Inactive Form (GIP 3-42): Formed through rapid inactivation of GIP 1-42 by the enzyme DPP-IV (Dipeptidyl Peptidase-IV).

Receptor and Expression:

• Receptor Presence: The GIP receptor is expressed in several cell types:
• Pancreatic Beta Cells: Where it stimulates insulin secretion.
• Adipocytes: Involved in fat metabolism and energy regulation.
• Osteoblastic Cells: Affecting bone metabolism and growth.

Clinical Relevance:

• Metabolic Syndrome: Modulation of GIP signaling is considered beneficial for improving conditions related to metabolic syndrome, such as type 2 diabetes and obesity.
• Measurement in Research: Monitoring both active GIP (GIP 1-42) and its inactive form (GIP 3-42) can provide insights into GIP's role in metabolic processes and disease states.

ELISA Kit Features:

• Purpose: Designed to measure both total Mouse GIP (1-42) and Rat GIP (3-42).
• Components: Includes all necessary reagents such as pre-coated plates, standards, buffers, and diluents for conducting quantitative enzyme-linked immunosorbent assays (ELISA).
• Control Set: Available separately upon request.

This ELISA kit is useful for researchers studying the role of GIP in various physiological and pathological conditions, offering a means to assess its activity and impact on metabolic health.

This ELISA Kit from Tecan IBL International is for research use only.

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