Bioprocessing Osmometer, OsmoTECH XT, Single-Sample Micro-Osmometer, 0-4000 mOsm/kg H2O

Advanced Instruments OsmoTECH XT Single-Sample Osmometer delivers best-in-class osmolality performance with intelligent freezing technology, precise measurements for complex and highly viscous samples, and full compliance with 21 CFR Part 11, GMP, and EU Annex 11. With a wide osmolality range (0–4000 mOsm/kg H₂O), small 20 μL sample volume, and robust data management, it streamlines workflows in bioprocessing, cell & gene therapy, and food & beverage industries. Ensure accuracy, compliance, and efficiency with OsmoTECH XT.

Best-in-class osmolality performance

• Intelligent freezing technology reliably and accurately tests a wide variety of samples including complex matrices and highly viscous samples (i.e. sugars and proteins)
• Small sample volume uses only 20 μLs for testing
• Fully supports 21 CFR Part 11, GMP, and EU Annex 11 compliance

OsmoTECH XT empowers labs with accurate and precise osmolality analysis for a wide range of liquid samples across bioprocessing and cell & gene therapy workflows.

Streamline your osmolality workflow with a user-friendly interface and ensure robust data integrity with compliance features to match any digital environment.

Highlighted features

• Widest Range Osmolality Testing
• Small Sample Size
• Intelligent Freezing Technology
• Intuitive Interface
• 21 CFR Part 11, GMP, EU Annex 11 Compliance
• Pharmacopeia Compliance

Confidence in your process and quality control

Osmolality testing with OsmoTECH XT ensures reliable and robust analysis providing you with confidence in the development of a quality therapeutic. The OsmoTECH XT unlocks the next generation of freezing point depression testing to determine the osmolality of even the most complex samples. Engineered in collaboration with scientists across bioprocessing workflows to address the unique user and data security pain points found throughout every stage of the bioprocessing workflow.

Product Features

Intelligent freezing technology

• Only 20 μL sample volume with optimized cooling engine
• Measure even the most complex samples with more accuracy and precision

Experience widest range of osmolality 0 - 4000 mOsm/kgH2O

• Measure high concentrated solutions such as proteins and sugars
• Remove dilutions

Supports compliance

• 21 CFR part 11 / EU Annex 11
• e-Signature
• Three level user access
• Password protection
• And more

GMP environment

• Pharmacopeia osmolality testing guidelines

Robust and flexible data management

• Network share (pdf & csv)
• Open Protocol Communication (OPC-UA)
• LIS (TCP/IP) Communication
• Bi-directional data management capability with OPC-UA to connect lab management (LIMS) and middleware software
• Active directory
• USB download
• Optional dot-matrix printer

One-step direct sampling

• Positive displacement sampler
• Aspirate highly viscous sample types (hyaluronate, cryopreservatives, etc.)

Preserve your audit trail

• Integrated barcode scanner for sample identification and reduced transcription errors
• Automatic, manual, synchronous back up
• Complete time-stamped record of usage, role, and actions requiring reason for settings changes
• Ability to annotate test results via the handy comments field

Simple user interface

• Large touchscreen

Optimized lab space

• Integrated consumable shelf
• Clean-room friendly consumables

Industry Applications

In Biotech Labs - Maximize biologic yield, quality, and purity by optimizing and ensuring the quality and consistency of your buffers, media, product, excipients, and process parameters.

In Food & Beverage Labs - Boost efficiency, ensure product quality, and maintain process consistency with osmolality testing from formulation to release.