Amyloid-beta (1-42) (Mouse/Rat) ELISA

Amyloid-beta (1-42) ELISA Kit

Purpose: The Amyloid-beta (1-42) ELISA Kit is specifically designed to measure endogenous Amyloid-beta (Aβ) (1-42) in rat and mouse samples. This assay provides precise quantification of Aβ (1-42), facilitating research into its role and variations in preclinical models of Alzheimer's disease.

Background: Amyloid-beta plaques, a hallmark of Alzheimer's disease, are primarily composed of the Aβ protein. Aβ is a peptide that typically consists of 40, 42, or occasionally 43 amino acids, produced through the cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Detailed characterization of various Aβ forms has been achieved using APP cDNA-transfected mouse neuroblastoma cell cultures.

In 1995, Saido and colleagues identified a distinct β-amyloid peptide variant, Aβ (N3pE), found in senile plaques. This variant begins with glutamate at the third amino-terminal position and is modified to pyroglutamate through intramolecular dehydration, distinguishing it from other Aβ forms.

Significance: Accurate measurement of Aβ (1-42) is essential for understanding its role in Alzheimer's disease and studying its variations in animal models. This ELISA kit allows for precise quantification of Aβ (1-42), providing valuable insights into its pathology and supporting the evaluation of therapeutic interventions.

Assay Details:

• Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
• Target: Endogenous Amyloid-beta (1-42)
• Specificity: Tailored for high specificity to Aβ (1-42) in rat and mouse samples
• Sensitivity: Optimized for accurate detection of low levels of Aβ (1-42)
• Format: Includes ready-to-use reagents and a detailed protocol for ease of use
• Sample Types: Suitable for various rodent biological samples

Utility: The Amyloid-beta (1-42) ELISA Kit is valuable for:

• Investigating the role of Aβ (1-42) in Alzheimer's disease models
• Evaluating the impact of treatments on Aβ (1-42) levels
• Conducting research into the dynamics and variations of Aβ (1-42) in preclinical studies

By providing accurate and reliable measurements of Aβ (1-42), this ELISA kit supports in-depth research and contributes to a better understanding of Alzheimer's disease and the development of effective treatments.

This ELISA Kit from Tecan IBL International is for research use only.

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