Amyloid-beta (1-42) High Sensitive ELISA

Amyloid-beta (1-42) Full-Length ELISA Kit

Purpose: The Amyloid-beta (1-42) Full-Length ELISA Kit is designed for the precise measurement of full-length human Amyloid-beta (Aβ) (1-42) with high specificity and sensitivity. This kit utilizes two highly specific antibodies targeting the C- and N-termini of the peptide, ensuring accurate detection of Aβ (1-42) levels.

Background: Alzheimer's disease, first identified by Dr. Alois Alzheimer in 1907, is a leading cause of dementia in the elderly. The disease is characterized by the accumulation of amyloid-beta (Aβ) plaques in the brain. Aβ is a peptide that can be composed of 40, 42, or occasionally 43 amino acids. It is generated from the cleavage of amyloid precursor protein (APP) by β- and γ-secretases. APP is a transmembrane protein with different isoforms, including those with 695, 751, or 770 amino acids.

Significant research has revealed various Aβ species, including the notable discovery in 1995 by Saido and colleagues of the Aβ (N3pE) variant. This variant features a glutamate at the third amino terminal position, modified to pyroglutamate through intramolecular dehydration, and is prominently found in senile plaques.

Significance: Accurate measurement of full-length Aβ (1-42) is crucial for understanding the role of this peptide in Alzheimer's disease pathology. The presence and levels of Aβ (1-42) are key indicators of disease progression and therapeutic efficacy. The use of this ELISA kit allows for detailed analysis of Aβ (1-42), aiding in research and development efforts related to Alzheimer's disease and related conditions.

Assay Details:

• Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
• Target: Full-length human Amyloid-beta (1-42)
• Specificity: Utilizes highly specific antibodies targeting both the C- and N-termini of the peptide
• Sensitivity: High sensitivity to accurately detect Aβ (1-42) even at low concentrations
• Format: Includes ready-to-use reagents and a comprehensive protocol for ease of use
• Sample Types: Compatible with various biological samples, including serum, plasma, and cerebrospinal fluid

Utility: The Amyloid-beta (1-42) Full-Length ELISA Kit is an essential tool for:

• Investigating the role of Aβ (1-42) in Alzheimer's disease
• Evaluating therapeutic interventions and their impact on Aβ (1-42) levels
• Conducting detailed biomarker studies for diagnosis and disease monitoring

By providing precise measurements of Aβ (1-42), this ELISA kit supports advanced research into Alzheimer's disease and contributes to the development of effective treatments and diagnostic tools.

This ELISA Kit from Tecan IBL International is for research use only.

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