Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Amyloid-beta (1-40) High-Specificity ELISA
Purpose: The Amyloid-beta (1-40) High-Specificity ELISA is designed to accurately measure endogenous Amyloid-beta (Aβ) (1-40) in rat and mouse samples. This high-specificity assay enables detailed analysis of Aβ (1-40) levels, supporting research into its role and variations in preclinical models.
Background: Amyloid-beta plaques are a defining feature of Alzheimer's disease and are primarily composed of the Aβ protein. Aβ is a peptide that can consist of 40, 42, or occasionally 43 amino acids, generated through the cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Various Aβ forms have been characterized, particularly through studies using APP cDNA-transfected mouse neuroblastoma cell lines.
Notably, in 1995, Saido and colleagues identified a distinct variant of Aβ, Aβ (N3pE), found in senile plaques. This variant starts with glutamate at the third amino-terminal position and is modified to pyroglutamate through intramolecular dehydration, setting it apart from other Aβ species.
Significance: Accurate measurement of Aβ (1-40) is crucial for understanding its role in Alzheimer's disease and its variations in animal models. This ELISA kit provides precise quantification of Aβ (1-40), which is essential for studying its involvement in disease mechanisms and evaluating potential therapeutic interventions.
Assay Details:
- Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
- Target: Endogenous Amyloid-beta (1-40)
- Specificity: High specificity for Aβ (1-40) in rat and mouse samples
- Sensitivity: Designed for accurate detection of low levels of Aβ (1-40)
- Format: Includes ready-to-use reagents and a detailed protocol for ease of use
- Sample Types: Compatible with various rodent biological samples
Utility: The Amyloid-beta (1-40) High-Specificity ELISA Kit is ideal for:
- Investigating the role of Aβ (1-40) in Alzheimer's disease models
- Assessing the effects of treatments on Aβ (1-40) levels
- Conducting comprehensive research into Aβ (1-40) variations and dynamics in preclinical studies
This ELISA kit supports advanced research into Alzheimer's disease, providing valuable data to enhance understanding and development of effective treatments.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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