Amyloid-beta (1-40) High Sensitive ELISA

Amyloid-beta (1-38) (FL) ELISA Kit

Purpose: The Amyloid-beta (1-38) (FL) ELISA Kit is designed to quantify human Amyloid-beta (Aβ) (1-38) with an intact N-terminus. This assay allows researchers to accurately measure Aβ (1-38) levels in various samples, providing crucial insights into Alzheimer's disease pathology and the effects of therapeutic interventions.

Background: Amyloid-beta plaques are a defining feature of Alzheimer's disease, composed predominantly of the Amyloid-beta protein (Aβ). This peptide, which can vary in length to include 40, 42, or occasionally 43 amino acids, is produced through the cleavage of amyloid precursor protein by β- and γ-secretases. The Aβ (1-38) form, with a complete N-terminal sequence, represents one of the several variants of Aβ.

Significant research, including a 2001 study by Edward H. Koo and colleagues, demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) can alter the secretion of different Aβ species. Specifically, NSAIDs were found to reduce Aβ42 levels while increasing Aβ38 levels, suggesting their potential role as γ-secretase modulators. As a result, measuring Aβ38 and Aβ42 levels has become essential for evaluating the impact of NSAIDs and other therapeutic agents.

Significance: Monitoring Aβ (1-38) levels is crucial for understanding the dynamics of amyloid-beta production and its role in Alzheimer's disease. This ELISA kit offers a precise method for measuring this specific Aβ variant, aiding in the development of treatments and providing insights into disease mechanisms. The ability to assess changes in Aβ (1-38) levels can also help in evaluating the efficacy of potential therapies, including NSAIDs and other modulators.

Assay Details:

• Detection Method: Enzyme-Linked Immunosorbent Assay (ELISA)
• Target: Human Amyloid-beta (1-38) with intact N-terminus
• Sensitivity: High sensitivity to detect low levels of Aβ (1-38)
• Format: Ready-to-use reagents and detailed protocol provided
• Sample Types: Suitable for various biological samples including serum, plasma, and cerebrospinal fluid

Utility: The Amyloid-beta (1-38) (FL) ELISA Kit is a valuable tool for researchers studying Alzheimer's disease and related conditions. It is particularly useful for:

• Investigating the role of Aβ (1-38) in disease progression
• Evaluating the effects of potential therapeutic agents, including NSAIDs
• Conducting biomarker studies for early diagnosis and monitoring disease status

By providing accurate and reliable measurements of Aβ (1-38), this ELISA kit supports ongoing research and therapeutic development efforts aimed at combating Alzheimer's disease.

This ELISA Kit from Tecan IBL International is for research use only.

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