Amyloid-beta (1-38) (FL) ELISA

Amyloid-beta (1-38) (FL) ELISA Overview

Purpose: This ELISA kit is specifically designed to measure human Amyloid-beta (1-38) (FL), which refers to the full-length peptide with a complete N-terminus. This form of Aβ is relevant for studies related to Alzheimer's disease and the effects of various treatments.

Background:

• Amyloid-beta (Aβ) Peptides: Aβ peptides are critical in the pathology of Alzheimer's disease. They are derived from the amyloid precursor protein (APP) through cleavage by β-secretase and γ-secretase. The resulting Aβ peptides can vary in length, with Aβ (1-38), Aβ (1-40), and Aβ (1-42) being common forms.
• Variant Detection: Aβ (1-38) is one of the less abundant forms compared to Aβ (1-40) and Aβ (1-42), but its levels are significant in understanding the overall dynamics of Aβ production and deposition.

Significance:

• Effects of NSAIDs: Research by Edward H. Koo and colleagues in 2001 demonstrated that NSAIDs can modulate γ-secretase activity, leading to decreased secretion of Aβ (1-42) and increased secretion of Aβ (1-38). This effect is thought to be related to the potential of NSAIDs to influence Alzheimer's disease progression by altering the balance of Aβ peptide variants.
• Biomarker Utility: Measuring Aβ (1-38) levels can provide insights into the efficacy of NSAIDs and other therapeutic interventions aimed at modifying Aβ peptide production. This makes Aβ (1-38) an important biomarker for evaluating drug effects and understanding the disease mechanism.

Assay Details:

• Measurement: This ELISA kit detects and quantifies human Aβ (1-38) with the complete N-terminus, providing accurate measurements of this specific peptide variant in biological samples, such as cerebrospinal fluid (CSF) or plasma.
• Application: The assay is particularly useful in research focused on Alzheimer's disease, especially in studies evaluating the impact of drugs that modulate Aβ production or in investigations of Aβ peptide dynamics in the context of disease progression.

Utility:

• Research Focus: By measuring Aβ (1-38), researchers can better understand how different therapeutic strategies, including NSAIDs, affect Aβ peptide profiles. This information is crucial for developing and assessing potential treatments for Alzheimer's disease.
• Clinical Insights: Monitoring Aβ (1-38) levels can help in evaluating the effectiveness of new drugs and in gaining a deeper understanding of the mechanisms underlying Alzheimer's disease, potentially guiding clinical decisions and therapeutic approaches.

This ELISA kit offers a valuable tool for researchers studying the role of Aβ (1-38) in Alzheimer's disease and assessing the impact of various treatments on Aβ peptide levels.

This ELISA Kit from Tecan IBL International is for research use only.

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