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in situ hybridization probes for COVID-19 coronavirus


in situ hybridization probes for COVID-19 coronavirusCOVID-19 (Coronavirus disease 2019) is caused by the positive stranded SARS-CoV-2 RNA virus in humans and is closely related to the bat-derived severe acute respiratory syndrome-like coronaviruses. Among the human viruses SARS-CoV-2 is most similar to SARS-CoV and MERS-CoV viruses that are responsible for the severe acute respiratory syndrome and middle eastern respiratory syndrome, respectively.

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How can the RNAscope™ technology support COVID-19 research?

The unparalleled sensitivity and specificity of the RNAscope™ technology allows direct visualization of the virus and estimates the viral load in any tissue and cells with morphological context. This technology eliminates the need for the costly and time-consuming development of specific antibodies for newly identified gene targets or pathogens such as the COVID-19 SARS-CoV-2 virus. Additionally, the RNAscope technology can be combined with immunohistochemistry (IHC) on the same slide for detection of RNA and protein simultaneously. The RNAscope probe can detect the SARS-CoV-2 spike protein mRNA and does not detect other coronaviruses.

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