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Advanced Glycation Endproducts


There are new competitive ELISA kits for advanced glycation endproducts:

When the formation of reactive oxygen species (ROS) exceeds the removal by scavenger systems, e.g. by the action of superoxide dismutase (SOD), catalase and peroxidases, this can lead to a multitude of pathological conditions:

  • Diabetes
  • Parkinson’s disease
  • Alzheimer’s disease
  • Rheumatoid arthritis
  • Inflammatory bowel diseases
  • Chronic inflammation
  • Sepsis

Excessive ROS and RNS can lead to DNA damage and alterated function of proteins, lipids and carbohydrates. Protein tyrosine nitration is a post-translational modification taken place as a result of a nitrating agent. Nitrotyrosine is formed in presence of the active metabolite nitric oxide (NO). NO and superoxide react in solution to form peroxynitrite, a strong protein-oxidizing agent. Peroxynitrite concentrations are reflected by monitoring nitrotyrosine residues, reflecting oxidative stress. Protein nitrotyrosylation can change, lower or even completely inhibit the catalytic activity of an enzyme.

Cat# Description
HIT501 Nitrotyrosine Competitive ELISA Quote me!

 

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